Recommended Dosage

1. Standard Dosage Range:
   • The typical dosage range for isotretinoin is 0.5 to 1 mg/kg/day. This dosage is usually divided into two doses taken with food to enhance absorption.
2. Cumulative Dose:
   • The cumulative dose over the course of treatment generally aims for 120 to 150 mg/kg of body weight. This total dose is often administered over a period of 4 to 6 months (approximately 16 to 24 weeks) depending on the patient’s response and tolerance.
3. Adjustments for Severe Cases:
   • In cases of severe acne, particularly where scarring is a concern, dosages may be adjusted up to 2 mg/kg/day, although this should be done cautiously and under strict medical supervision.
4. Low-Dose Regimens:
   • Recent studies suggest that lower doses (e.g., 0.1 to 0.3 mg/kg/day) can be effective and may lead to fewer side effects while still achieving satisfactory acne clearance46. This approach can also help in reducing the risk of adverse effects associated with higher doses.